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  2. Historically, a express apprehension of the physiologic chemical mechanism of erections controlled the treatment of ED to vacuum-chokepoint devices, prosthetic implants, intracavernosal injections,
    and intraurethral suppositories.4 Since its advent,
    the year of agents known as type-5 phosphodiesterase
    (PDE5) inhibitors has revolutionized the management of ED.
    PDE5 inhibitors consume get the first-line therapy for ED,
    as suggested by the American English Urological Affiliation (AUA) and the European Connection of Urology

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